ISO 23921:2020

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke with an intense smoking regime — Method using LC-MS/MS

Publication date: Sep 30, 2020

General information

Current stage: 90.20 Effective date: Jul 15, 2025

Originator: ISO

Owner: ISO/TC 126

Type: International Standard

ICS: 65.160

Languages: English

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Status: Published

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Scope

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke with the intense smoking regime specified in ISO 20778 by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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PUBLISHED
ISO 23921:2020
90.20 Standard under periodical review
Jul 15, 2025

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