ISO 19290:2021

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke — Method using LC-MS/MS

Publication date: Feb 3, 2021

General information

Current stage: 90.20 Effective date: Jan 15, 2026

Originator: ISO

Owner: ISO/TC 126

Type: International Standard

ICS: 65.160

Languages: English French

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Status: Published

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Scope

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Life cycle

PREVIOUSLY

WITHDRAWN
ISO 19290:2016

NOW

PUBLISHED
ISO 19290:2021
90.20 Standard under periodical review
Jan 15, 2026

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