SSH EN 16418:2014

Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)

Publication date: Oct 24, 2014

General information

Current stage: 60.60 Effective date: Oct 24, 2014

Originator: DPS

Owner: DPS/KT 172

Type: European Norm

ICS: 85.060

Languages: English

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Status: Published

PDF - ALL 3,570

Paper - ALL 3,570

CD - ALL 3,570

PDF and Paper - ALL 7,140

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This European Standard specifies a test method for the laboratory assessment of the potential cytotoxic effect of paper and board intended to come into contact with foodstuffs using specifically the HepG2 cell line.
Compared to the EN 15845[1], HepG2 cells are more representative of a human oral exposure to xenobiotics, due to the presence in the cells of phase I, II and III enzymes of the metabolism.

SSH EN 16418:2014

Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2)

General information

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Adopted from EN 16418:2014